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micronucleus terminate in t-loops, even so the minichromosomes in its macronucleus lack t-loops and they are simply capped by a tenacious binding protein. A single could argue that the minichromosomes usually are not accurate chromosomes, as they lack centromeres and they are not passed down to progeny.Telomerase activity continues to be tightly co

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, 2001). This constrained malignant progression relates prominently on the activation of p53 in aspiring cancer cells enduring telomere dysfunction. Inactivation on the p53 tumor suppressor is Just about the most frequent situations in human epithelial cancers (Brosh and Rotter, 2009) and also the position of p53 can dictate whether or not telomere

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